6Q20

Crystal structure of human 1E01 Fab in complex with influenza virus neuraminidase from A/Japan/305/1957 (H2N2)

Summary for 6Q20

Entry DOI	10.2210/pdb6q20/pdb
Descriptor	Neuraminidase, 1E01 Fab kappa light chain, 1E01 Fab IgG1 heavy chain, ... (8 entities in total)
Functional Keywords	broadly protective human antibody, neuraminidase, inhibition, active site, antibody-neuraminidase complex, viral protein, hydrolase-immune system complex, hydrolase/immune system
Biological source	Influenza A virus (strain A/Japan/305/1957 H2N2) More
Total number of polymer chains	3
Total formula weight	95205.56
Authors	Zhu, X.,Wilson, I.A. (deposition date: 2019-08-06, release date: 2019-10-23, Last modification date: 2023-10-11)
Primary citation	Stadlbauer, D.,Zhu, X.,McMahon, M.,Turner, J.S.,Wohlbold, T.J.,Schmitz, A.J.,Strohmeier, S.,Yu, W.,Nachbagauer, R.,Mudd, P.A.,Wilson, I.A.,Ellebedy, A.H.,Krammer, F. Broadly protective human antibodies that target the active site of influenza virus neuraminidase. Science, 366:499-504, 2019 Cited by PubMed: 31649200 DOI: 10.1126/science.aay0678 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.45 Å)

Structure validation