6PJX
Crystal Structure of G Protein-Coupled Receptor Kinase 5 (GRK5) in Complex with Calmodulin (CaM)
Summary for 6PJX
Entry DOI | 10.2210/pdb6pjx/pdb |
Related | 4TNB 4TND |
Descriptor | G protein-coupled receptor kinase 5, Calmodulin, SANGIVAMYCIN, ... (5 entities in total) |
Functional Keywords | g protein-coupled receptor (gpcr); g protein-coupled receptor kinase; phosphorylation; protein kinase; receptor regulation; signal transduction; calmodulin; calcium binding protein, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 85079.49 |
Authors | Bhardwaj, A.,Komolov, K.E.,Sulon, S.,Benovic, J.L. (deposition date: 2019-06-28, release date: 2020-12-09, Last modification date: 2023-10-11) |
Primary citation | Komolov, K.E.,Sulon, S.M.,Bhardwaj, A.,van Keulen, S.C.,Duc, N.M.,Laurinavichyute, D.K.,Lou, H.J.,Turk, B.E.,Chung, K.Y.,Dror, R.O.,Benovic, J.L. Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting. Mol.Cell, 81:323-, 2021 Cited by PubMed: 33321095DOI: 10.1016/j.molcel.2020.11.026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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