6PJX
Crystal Structure of G Protein-Coupled Receptor Kinase 5 (GRK5) in Complex with Calmodulin (CaM)
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0004703 | molecular_function | G protein-coupled receptor kinase activity |
A | 0005080 | molecular_function | protein kinase C binding |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005543 | molecular_function | phospholipid binding |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005886 | cellular_component | plasma membrane |
A | 0006468 | biological_process | protein phosphorylation |
A | 0006915 | biological_process | apoptotic process |
A | 0007165 | biological_process | signal transduction |
A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
A | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
A | 0007217 | biological_process | tachykinin receptor signaling pathway |
A | 0008277 | biological_process | regulation of G protein-coupled receptor signaling pathway |
A | 0008284 | biological_process | positive regulation of cell population proliferation |
A | 0008289 | molecular_function | lipid binding |
A | 0009966 | biological_process | regulation of signal transduction |
A | 0016055 | biological_process | Wnt signaling pathway |
A | 0016607 | cellular_component | nuclear speck |
A | 0031965 | cellular_component | nuclear membrane |
A | 0043066 | biological_process | negative regulation of apoptotic process |
A | 0045444 | biological_process | fat cell differentiation |
A | 0046777 | biological_process | protein autophosphorylation |
A | 0047696 | molecular_function | beta-adrenergic receptor kinase activity |
A | 0051726 | biological_process | regulation of cell cycle |
B | 0005509 | molecular_function | calcium ion binding |
B | 0030234 | molecular_function | enzyme regulator activity |
B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 17 |
Details | binding site for residue SGV A 601 |
Chain | Residue |
A | LEU192 |
A | LEU318 |
A | SER328 |
A | HOH731 |
A | HOH810 |
A | HOH952 |
A | HOH1013 |
A | HOH1015 |
A | HOH1049 |
A | GLY193 |
A | LYS194 |
A | ALA213 |
A | LEU263 |
A | THR264 |
A | MET266 |
A | ASP270 |
A | GLU315 |
site_id | AC2 |
Number of Residues | 7 |
Details | binding site for residue CA B 201 |
Chain | Residue |
B | ASP56 |
B | ASP58 |
B | ASN60 |
B | THR62 |
B | GLU67 |
B | HOH320 |
B | HOH325 |
site_id | AC3 |
Number of Residues | 6 |
Details | binding site for residue CA B 202 |
Chain | Residue |
A | HOH806 |
B | ASP20 |
B | ASP22 |
B | ASP24 |
B | THR26 |
B | GLU31 |
Functional Information from PROSITE/UniProt
site_id | PS00018 |
Number of Residues | 13 |
Details | EF_HAND_1 EF-hand calcium-binding domain. DKDGDGTITtkEL |
Chain | Residue | Details |
B | ASP20-LEU32 | |
B | ASP56-PHE68 | |
B | ASP93-LEU105 | |
B | ASP129-PHE141 |
site_id | PS00107 |
Number of Residues | 33 |
Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGFGEVCaCqvratgkmyackrlekk.RIKK |
Chain | Residue | Details |
A | LEU192-LYS224 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | ASP311 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
Chain | Residue | Details |
A | LEU192 | |
A | LYS215 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000269|PubMed:8144599, ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | SER484 |
site_id | SWS_FT_FI4 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:8144599, ECO:0007744|PubMed:18669648 |
Chain | Residue | Details |
A | THR485 |
site_id | SWS_FT_FI5 |
Number of Residues | 1 |
Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8VEB1 |
Chain | Residue | Details |
A | SER579 |