6PJX
Crystal Structure of G Protein-Coupled Receptor Kinase 5 (GRK5) in Complex with Calmodulin (CaM)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | G protein-coupled receptor kinase 5 | polymer | 591 | 67968.7 | 1 | UniProt (P34947) Pfam (PF00615) Pfam (PF00069) | Homo sapiens (Human) | G protein-coupled receptor kinase GRK5 |
| 2 | B (B) | Calmodulin | polymer | 148 | 16721.3 | 1 | UniProt (A0A094NJQ6) Pfam (PF13499) | Podiceps cristatus (Great crested grebe) | |
| 3 | C (A) | SANGIVAMYCIN | non-polymer | 309.3 | 1 | Chemie (SGV) | |||
| 4 | D, E (B) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 520 | Chemie (HOH) |
Sequence modifications
A: 1 - 590 (UniProt: P34947)
| PDB | External Database | Details |
|---|---|---|
| Ace 0 | - | acetylation |
| Lys 104 | Glu 104 | engineered mutation |
| His 304 | Arg 304 | engineered mutation |
| Glu 438 | Gly 438 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 84690.1 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 389.4 | |
| All* | Total formula weight | 85079.5 |
