6PJX

Crystal Structure of G Protein-Coupled Receptor Kinase 5 (GRK5) in Complex with Calmodulin (CaM)

6PJX の概要

• エントリーDOI: 10.2210/pdb6pjx/pdb
• 関連するPDBエントリー: 4TNB 4TND
• 分子名称: G protein-coupled receptor kinase 5, Calmodulin, SANGIVAMYCIN, ... (5 entities in total)
• 機能のキーワード: g protein-coupled receptor (gpcr); g protein-coupled receptor kinase; phosphorylation; protein kinase; receptor regulation; signal transduction; calmodulin; calcium binding protein, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 85079.49

構造登録者

Bhardwaj, A.,Komolov, K.E.,Sulon, S.,Benovic, J.L. (登録日: 2019-06-28, 公開日: 2020-12-09, 最終更新日: 2023-10-11)

• 主引用文献: Komolov, K.E.,Sulon, S.M.,Bhardwaj, A.,van Keulen, S.C.,Duc, N.M.,Laurinavichyute, D.K.,Lou, H.J.,Turk, B.E.,Chung, K.Y.,Dror, R.O.,Benovic, J.L.; Structure of a GRK5-Calmodulin Complex Reveals Molecular Mechanism of GRK Activation and Substrate Targeting.; Mol.Cell, 81:323-, 2021; PubMed: 33321095; DOI: 10.1016/j.molcel.2020.11.026

実験手法

X-RAY DIFFRACTION (1.96 Å)