6PH6

Ternary complex crystal structure of DNA polymerase Beta with 2nt-gap with dCTP bound downstream

Summary for 6PH6

• Entry DOI: 10.2210/pdb6ph6/pdb
• Descriptor: DNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*G)-3'), ... (8 entities in total)
• Functional Keywords: dna polymerase beta, conformational change, enzyme mechanism, misalignment mutagenesis, transcription-dna complex, transcription/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 47980.43

Authors

Batra, V.K.,Wilson, S.H. (deposition date: 2019-06-25, release date: 2019-12-11, Last modification date: 2023-10-11)

• Primary citation: Howard, M.J.,Cavanaugh, N.A.,Batra, V.K.,Shock, D.D.,Beard, W.A.,Wilson, S.H.; DNA polymerase beta nucleotide-stabilized template misalignment fidelity depends on local sequence context.; J.Biol.Chem., 295:529-538, 2020; PubMed: 31801827; DOI: 10.1074/jbc.RA119.010594

Experimental method

X-RAY DIFFRACTION (2.6 Å)