6PGU
Crystal structure of the p300 acetyltransferase domain with allosteric inhibitor CPI-076 and CoA
Summary for 6PGU
Entry DOI | 10.2210/pdb6pgu/pdb |
Descriptor | Histone acetyltransferase p300, COENZYME A, N-(thiophen-2-yl)acetamide, ... (4 entities in total) |
Functional Keywords | ep300, p300 acetyltransferase, chromatin modification, epigenetics, inhibitor, allosteric, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 76188.41 |
Authors | Gardberg, A.S.,Poy, F.,Setser, J. (deposition date: 2019-06-24, release date: 2019-10-23, Last modification date: 2024-05-22) |
Primary citation | Gardberg, A.S.,Huhn, A.J.,Cummings, R.,Bommi-Reddy, A.,Poy, F.,Setser, J.,Vivat, V.,Brucelle, F.,Wilson, J. Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT. Struct Dyn., 6:054702-054702, 2019 Cited by PubMed: 31649965DOI: 10.1063/1.5119336 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.72 Å) |
Structure validation
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