6PF1

Crystal structure of the p300 acetyltransferase domain with allosteric inhibitor CPI-090 and CoA

Summary for 6PF1

• Entry DOI: 10.2210/pdb6pf1/pdb
• Descriptor: Histone acetyltransferase p300, COENZYME A, 3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methyl-1H-indole, ... (4 entities in total)
• Functional Keywords: ep300, p300 acetyltransferase, chromatin modification, epigenetics, inhibitor, allosteric, transferase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 80325.55

Authors

Gardberg, A.S. (deposition date: 2019-06-21, release date: 2019-10-23, Last modification date: 2024-03-13)

• Primary citation: Gardberg, A.S.,Huhn, A.J.,Cummings, R.,Bommi-Reddy, A.,Poy, F.,Setser, J.,Vivat, V.,Brucelle, F.,Wilson, J.; Make the right measurement: Discovery of an allosteric inhibition site for p300-HAT.; Struct Dyn., 6:054702-054702, 2019; PubMed: 31649965; DOI: 10.1063/1.5119336

Experimental method

X-RAY DIFFRACTION (2.32 Å)