6PF1

Crystal structure of the p300 acetyltransferase domain with allosteric inhibitor CPI-090 and CoA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Histone acetyltransferase p300	polymer	338	39084.5	2	UniProt (Q09472) Pfam (PF08214) In PDB	Homo sapiens (Human)	p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein propionyltransferase p300,p300 HAT,E1A-associated protein p300,Histone butyryltransferase p300,Histone crotonyltransferase p300,Protein propionyltransferase p300
2	A, B	COENZYME A	non-polymer		767.5	2	Chemie (COA)
3	A, B	3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-2-methyl-1H-indole	non-polymer		310.7	2	Chemie (OJ7)
4		water	water		18.0	86	Chemie (HOH)

Sequence modifications

A, B: 1287 - 1513 (UniProt: Q09472)

PDB	External Database	Details
Met 1270	-	initiating methionine
His 1271	-	expression tag
His 1272	-	expression tag
His 1273	-	expression tag
His 1274	-	expression tag
His 1275	-	expression tag
His 1276	-	expression tag
Gly 1277	-	expression tag
Ser 1278	-	expression tag
Glu 1279	-	expression tag
Asn 1280	-	expression tag
Leu 1281	-	expression tag
Tyr 1282	-	expression tag
Phe 1283	-	expression tag
Gln 1284	-	expression tag
Gly 1285	-	expression tag
Ser 1286	-	expression tag
Phe 1467	Tyr 1467	engineered mutation

A, B: 1514 - 1580 (PDB: 6PF1)
A, B: 1581 - 1663 (UniProt: Q09472)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	78169.1
Non-Polymers*	Number of molecules	4
	Total formula weight	2156.5
All*	Total formula weight	80325.5

*Water molecules are not included.