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6PF1

Crystal structure of the p300 acetyltransferase domain with allosteric inhibitor CPI-090 and CoA

Functional Information from GO Data
ChainGOidnamespacecontents
A0004402molecular_functionhistone acetyltransferase activity
A0006355biological_processregulation of DNA-templated transcription
B0004402molecular_functionhistone acetyltransferase activity
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues25
Detailsbinding site for residue COA A 1701
ChainResidue
ALEU1398
ATYR1446
ALYS1456
AILE1457
APRO1458
AARG1462
ATRP1466
AHOH1802
AHOH1811
AHOH1816
AHOH1825
AASP1399
AHOH1829
AHOH1834
AHOH1844
AHOH1845
AHOH1847
AHOH1851
ASER1400
AARG1410
ATHR1411
ATYR1414
ATRP1436
ACYS1438
APRO1440

site_idAC2
Number of Residues13
Detailsbinding site for residue OJ7 A 1702
ChainResidue
AHIS1434
AILE1435
AILE1486
AGLN1489
AALA1490
AASP1493
ALEU1495
ALEU1501
APRO1502
AASP1507
ATRP1509
APHE1595
APHE1596

site_idAC3
Number of Residues19
Detailsbinding site for residue COA B 1701
ChainResidue
BLEU1398
BASP1399
BSER1400
BARG1410
BTHR1411
BTYR1414
BTRP1436
BCYS1438
BPRO1440
BTYR1446
BLYS1456
BILE1457
BPRO1458
BARG1462
BLEU1463
BTRP1466
BTHR1496
BHOH1808
BHOH1814

site_idAC4
Number of Residues14
Detailsbinding site for residue OJ7 B 1702
ChainResidue
BTYR1394
BHIS1434
BILE1435
BILE1486
BGLN1489
BALA1490
BASP1493
BLEU1501
BPRO1502
BASP1507
BTRP1509
BPHE1595
BPHE1596
BVAL1597

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsBINDING: BINDING => ECO:0000269|PubMed:24819397
ChainResidueDetails
ALEU1398
BTRP1466
AARG1410
AILE1457
AARG1462
ATRP1466
BLEU1398
BARG1410
BILE1457
BARG1462

site_idSWS_FT_FI2
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17065153
ChainResidueDetails
ALYS1336
ALYS1473
BLYS1336
BLYS1473

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546
ChainResidueDetails
ALYS1499
BLYS1499

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:18995842, ECO:0007744|PubMed:19608861
ChainResidueDetails
AILE1598
AALA1602
BILE1598
BALA1602

site_idSWS_FT_FI5
Number of Residues2
DetailsMOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546, ECO:0000269|PubMed:18995842
ChainResidueDetails
AALA1605
BALA1605

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: N6-acetyllysine; by autocatalysis => ECO:0000269|PubMed:15004546, ECO:0007744|PubMed:19608861
ChainResidueDetails
APRO1610
AASP1616
BPRO1610
BASP1616

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
APRO1611
ALYS1583
BPRO1611
BLYS1583

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000269|PubMed:15004546, ECO:0007744|PubMed:19608861
ChainResidueDetails
AASP1614
BASP1614

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PDB entries from 2024-07-17

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