6P9Z

Staphylococcus aureus Dihydrofolate reductase in complex with NADPH and Methotrexate

Summary for 6P9Z

Entry DOI	10.2210/pdb6p9z/pdb
Descriptor	Dihydrofolate reductase, METHOTREXATE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (5 entities in total)
Functional Keywords	dhfr, methotrexate, antifolate, nadph, antimicrobial protein, oxidoreductase
Biological source	Staphylococcus aureus
Total number of polymer chains	1
Total formula weight	19305.49
Authors	Reeve, S.M.,Wright, D.L. (deposition date: 2019-06-10, release date: 2019-10-23, Last modification date: 2023-10-11)
Primary citation	Reeve, S.M.,Si, D.,Krucinska, J.,Yan, Y.,Viswanathan, K.,Wang, S.,Holt, G.T.,Frenkel, M.S.,Ojewole, A.A.,Estrada, A.,Agabiti, S.S.,Alverson, J.B.,Gibson, N.D.,Priestley, N.D.,Wiemer, A.J.,Donald, B.R.,Wright, D.L. Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin ResistantStaphylococcus aureus. Acs Infect Dis., 5:1896-1906, 2019 Cited by PubMed: 31565920 DOI: 10.1021/acsinfecdis.9b00222 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.86 Å)

Structure validation