6P8H

Crystal structure of CDK4 in complex with CyclinD1 and P21

6P8H の概要

• エントリーDOI: 10.2210/pdb6p8h/pdb
• 分子名称: G1/S-specific cyclin-D1, Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1 (3 entities in total)
• 機能のキーワード: cyclin-dependent kinase, kinase inhibitor, cell cycle, transferase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 71480.49

構造登録者

Guiley, K.Z.,Stevenson, J.W.,Lou, K.,Barkovich, K.J.,Bunch, K.,Tripathi, S.M.,Shokat, K.M.,Rubin, S.M. (登録日: 2019-06-07, 公開日: 2019-12-25, 最終更新日: 2023-10-11)

• 主引用文献: Guiley, K.Z.,Stevenson, J.W.,Lou, K.,Barkovich, K.J.,Kumarasamy, V.,Wijeratne, T.U.,Bunch, K.L.,Tripathi, S.,Knudsen, E.S.,Witkiewicz, A.K.,Shokat, K.M.,Rubin, S.M.; p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.; Science, 366:-, 2019; PubMed: 31831640; DOI: 10.1126/science.aaw2106

実験手法

X-RAY DIFFRACTION (3.19 Å)