6OVG

L-Methionine Depletion with an Engineered Human Enzyme Disrupts Prostate Cancer Metabolism

6OVG の概要

• エントリーDOI: 10.2210/pdb6ovg/pdb
• 分子名称: Cystathionine gamma-lyase, SULFATE ION (3 entities in total)
• 機能のキーワード: engineering, lyase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 365920.44

構造登録者

Yan, W.,Irani, S.,Zhang, J. (登録日: 2019-05-07, 公開日: 2020-04-22, 最終更新日: 2023-11-15)

• 主引用文献: Lu, W.C.,Saha, A.,Yan, W.,Garrison, K.,Lamb, C.,Pandey, R.,Irani, S.,Lodi, A.,Lu, X.,Tiziani, S.,Zhang, Y.J.,Georgiou, G.,DiGiovanni, J.,Stone, E.; Enzyme-mediated depletion of serum l-Met abrogates prostate cancer growth via multiple mechanisms without evidence of systemic toxicity.; Proc.Natl.Acad.Sci.USA, 117:13000-13011, 2020; PubMed: 32434918; DOI: 10.1073/pnas.1917362117

実験手法

X-RAY DIFFRACTION (2.719 Å)