6OUG

Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct

Summary for 6OUG

Entry DOI	10.2210/pdb6oug/pdb
Related	6BMZ 6NV1
Descriptor	Matrix protein 2, (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine (3 entities in total)
Functional Keywords	viral protein, proton channel, membrane protein
Biological source	Influenza A virus (strain A/Memphis/1/1971 H3N2)
Total number of polymer chains	8
Total formula weight	38675.94
Authors	Thomaston, J.L.,Liu, L.,DeGrado, W.F. (deposition date: 2019-05-04, release date: 2020-01-15, Last modification date: 2023-10-11)
Primary citation	Thomaston, J.L.,Konstantinidi, A.,Liu, L.,Lambrinidis, G.,Tan, J.,Caffrey, M.,Wang, J.,Degrado, W.F.,Kolocouris, A. X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance. Biochemistry, 59:627-634, 2020 Cited by PubMed: 31894969 DOI: 10.1021/acs.biochem.9b00971 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.01 Å)

Structure validation