6OUG

Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	Matrix protein 2	polymer	41	4779.7	8	UniProt (Q3YPZ4) Pfam (PF00599)	Influenza A virus (strain A/Memphis/1/1971 H3N2)	Proton channel protein M2
2	I, J (D, E)	(1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine	non-polymer		219.4	2	Chemie (E01)
3	K, L, M, N, O... (A, B, C, D, E...)	water	water		18.0	7	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F, G, H: 21 - 61 (UniProt: Q3YPZ4)

PDB	External Database	Details
Ala 27	Val 27	engineered mutation
Ser 50	Cys 50	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	38237.2
Non-Polymers*	Number of molecules	2
	Total formula weight	438.7
All*	Total formula weight	38675.9

*Water molecules are not included.