6OUG
Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015078 | molecular_function | proton transmembrane transporter activity |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0055036 | cellular_component | virion membrane |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0015078 | molecular_function | proton transmembrane transporter activity |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0055036 | cellular_component | virion membrane |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0015078 | molecular_function | proton transmembrane transporter activity |
| C | 0033644 | cellular_component | host cell membrane |
| C | 0055036 | cellular_component | virion membrane |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0015078 | molecular_function | proton transmembrane transporter activity |
| D | 0033644 | cellular_component | host cell membrane |
| D | 0055036 | cellular_component | virion membrane |
| D | 1902600 | biological_process | proton transmembrane transport |
| E | 0015078 | molecular_function | proton transmembrane transporter activity |
| E | 0033644 | cellular_component | host cell membrane |
| E | 0055036 | cellular_component | virion membrane |
| E | 1902600 | biological_process | proton transmembrane transport |
| F | 0015078 | molecular_function | proton transmembrane transporter activity |
| F | 0033644 | cellular_component | host cell membrane |
| F | 0055036 | cellular_component | virion membrane |
| F | 1902600 | biological_process | proton transmembrane transport |
| G | 0015078 | molecular_function | proton transmembrane transporter activity |
| G | 0033644 | cellular_component | host cell membrane |
| G | 0055036 | cellular_component | virion membrane |
| G | 1902600 | biological_process | proton transmembrane transport |
| H | 0015078 | molecular_function | proton transmembrane transporter activity |
| H | 0033644 | cellular_component | host cell membrane |
| H | 0055036 | cellular_component | virion membrane |
| H | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue E01 D 101 |
| Chain | Residue |
| A | ALA30 |
| A | SER31 |
| B | SER31 |
| C | ALA30 |
| D | ALA30 |
| D | SER31 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue E01 E 101 |
| Chain | Residue |
| F | SER31 |
| G | SER31 |
| H | ALA30 |
| H | SER31 |
| E | ALA30 |
| E | SER31 |
| F | ALA30 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 160 |
| Details | TRANSMEM: Helical; Signal-anchor for type III membrane protein => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | SER23-LEU43 | |
| B | SER23-LEU43 | |
| C | SER23-LEU43 | |
| D | SER23-LEU43 | |
| E | SER23-LEU43 | |
| F | SER23-LEU43 | |
| G | SER23-LEU43 | |
| H | SER23-LEU43 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | SITE: Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | HIS37 | |
| B | HIS37 | |
| C | HIS37 | |
| D | HIS37 | |
| E | HIS37 | |
| F | HIS37 | |
| G | HIS37 | |
| H | HIS37 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | SITE: Seems to be involved in pH gating => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | TRP41 | |
| B | TRP41 | |
| C | TRP41 | |
| D | TRP41 | |
| E | TRP41 | |
| F | TRP41 | |
| G | TRP41 | |
| H | TRP41 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | LIPID: S-palmitoyl cysteine; by host => ECO:0000255|HAMAP-Rule:MF_04069 |
| Chain | Residue | Details |
| A | SER50 | |
| B | SER50 | |
| C | SER50 | |
| D | SER50 | |
| E | SER50 | |
| F | SER50 | |
| G | SER50 | |
| H | SER50 |
