6OUG

Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor, TM + cytosolic helix construct

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015078	molecular_function	proton transmembrane transporter activity
A	0033644	cellular_component	host cell membrane
A	0055036	cellular_component	virion membrane
A	1902600	biological_process	proton transmembrane transport
B	0015078	molecular_function	proton transmembrane transporter activity
B	0033644	cellular_component	host cell membrane
B	0055036	cellular_component	virion membrane
B	1902600	biological_process	proton transmembrane transport
C	0015078	molecular_function	proton transmembrane transporter activity
C	0033644	cellular_component	host cell membrane
C	0055036	cellular_component	virion membrane
C	1902600	biological_process	proton transmembrane transport
D	0015078	molecular_function	proton transmembrane transporter activity
D	0033644	cellular_component	host cell membrane
D	0055036	cellular_component	virion membrane
D	1902600	biological_process	proton transmembrane transport
E	0015078	molecular_function	proton transmembrane transporter activity
E	0033644	cellular_component	host cell membrane
E	0055036	cellular_component	virion membrane
E	1902600	biological_process	proton transmembrane transport
F	0015078	molecular_function	proton transmembrane transporter activity
F	0033644	cellular_component	host cell membrane
F	0055036	cellular_component	virion membrane
F	1902600	biological_process	proton transmembrane transport
G	0015078	molecular_function	proton transmembrane transporter activity
G	0033644	cellular_component	host cell membrane
G	0055036	cellular_component	virion membrane
G	1902600	biological_process	proton transmembrane transport
H	0015078	molecular_function	proton transmembrane transporter activity
H	0033644	cellular_component	host cell membrane
H	0055036	cellular_component	virion membrane
H	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue E01 D 101

Chain	Residue
A	ALA30
A	SER31
B	SER31
C	ALA30
D	ALA30
D	SER31

---

site_id	AC2
Number of Residues	7
Details	binding site for residue E01 E 101

Chain	Residue
F	SER31
G	SER31
H	ALA30
H	SER31
E	ALA30
E	SER31
F	ALA30

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	140
Details	Transmembrane: {"description":"Helical; Signal-anchor for type III membrane protein","evidences":[{"source":"HAMAP-Rule","id":"MF_04069","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Site: {"description":"Essential for channel activity, possibly by being protonated during channel activation, and by forming the channel gate and the selective filter","evidences":[{"source":"HAMAP-Rule","id":"MF_04069","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Site: {"description":"Seems to be involved in pH gating","evidences":[{"source":"HAMAP-Rule","id":"MF_04069","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Lipidation: {"description":"S-palmitoyl cysteine; by host","evidences":[{"source":"HAMAP-Rule","id":"MF_04069","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---