6OQX
Human Liver Receptor Homolog-1 bound to the agonist 5N and a fragment of the Tif2 coregulator
Summary for 6OQX
Entry DOI | 10.2210/pdb6oqx/pdb |
Descriptor | Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, (8beta,11alpha,12alpha)-8-(1-phenylethenyl)-1,6:7,14-dicycloprosta-1,3,5,7(14)-tetraen-11-yl sulfamate, ... (4 entities in total) |
Functional Keywords | nuclear hormone receptor, agonist, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 30606.38 |
Authors | Mays, S.G.,Ortlund, E.A. (deposition date: 2019-04-29, release date: 2019-08-28, Last modification date: 2023-10-11) |
Primary citation | Mays, S.G.,Flynn, A.R.,Cornelison, J.L.,Okafor, C.D.,Wang, H.,Wang, G.,Huang, X.,Donaldson, H.N.,Millings, E.J.,Polavarapu, R.,Moore, D.D.,Calvert, J.W.,Jui, N.T.,Ortlund, E.A. Development of the First Low Nanomolar Liver Receptor Homolog-1 Agonist through Structure-guided Design. J.Med.Chem., 62:11022-11034, 2019 Cited by PubMed: 31419141DOI: 10.1021/acs.jmedchem.9b00753 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.004 Å) |
Structure validation
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