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6OPH

phosphorylated ERK2 with GDC-0994

Summary for 6OPH
Entry DOI10.2210/pdb6oph/pdb
DescriptorMitogen-activated protein kinase 1, 1-[(1~{S})-1-(4-chloranyl-3-fluoranyl-phenyl)-2-oxidanyl-ethyl]-4-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]pyridin-2-one (3 entities in total)
Functional Keywordssignaling protein, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight41574.89
Authors
Vigers, G.P.,Smith, D. (deposition date: 2019-04-25, release date: 2019-07-31, Last modification date: 2023-11-15)
Primary citationPegram, L.M.,Liddle, J.C.,Xiao, Y.,Hoh, M.,Rudolph, J.,Iverson, D.B.,Vigers, G.P.,Smith, D.,Zhang, H.,Wang, W.,Moffat, J.G.,Ahn, N.G.
Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2.
Proc.Natl.Acad.Sci.USA, 116:15463-15468, 2019
Cited by
PubMed: 31311868
DOI: 10.1073/pnas.1906824116
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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