6NVL
FGFR1 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide
Summary for 6NVL
Entry DOI | 10.2210/pdb6nvl/pdb |
Descriptor | Fibroblast growth factor receptor 1, SULFATE ION, N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide, ... (4 entities in total) |
Functional Keywords | transferase-transferase inhibitor complex, transferase, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 143115.41 |
Authors | Lin, X.,Smaill, J.B.,Squire, C.J. (deposition date: 2019-02-05, release date: 2019-07-10, Last modification date: 2023-10-11) |
Primary citation | Lin, X.,Yosaatmadja, Y.,Kalyukina, M.,Middleditch, M.J.,Zhang, Z.,Lu, X.,Ding, K.,Patterson, A.V.,Smaill, J.B.,Squire, C.J. Rotational Freedom, Steric Hindrance, and Protein Dynamics Explain BLU554 Selectivity for the Hinge Cysteine of FGFR4. Acs Med.Chem.Lett., 10:1180-1186, 2019 Cited by PubMed: 31413803DOI: 10.1021/acsmedchemlett.9b00196 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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