6NVL
FGFR1 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004713 | molecular_function | protein tyrosine kinase activity |
| A | 0005007 | molecular_function | fibroblast growth factor receptor activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006468 | biological_process | protein phosphorylation |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004713 | molecular_function | protein tyrosine kinase activity |
| B | 0005007 | molecular_function | fibroblast growth factor receptor activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0006468 | biological_process | protein phosphorylation |
| C | 0004672 | molecular_function | protein kinase activity |
| C | 0004713 | molecular_function | protein tyrosine kinase activity |
| C | 0005007 | molecular_function | fibroblast growth factor receptor activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0006468 | biological_process | protein phosphorylation |
| D | 0004672 | molecular_function | protein kinase activity |
| D | 0004713 | molecular_function | protein tyrosine kinase activity |
| D | 0005007 | molecular_function | fibroblast growth factor receptor activity |
| D | 0005524 | molecular_function | ATP binding |
| D | 0006468 | biological_process | protein phosphorylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 801 |
| Chain | Residue |
| A | ARG570 |
| A | ARG661 |
| A | LEU662 |
| A | LYS665 |
| A | TRP666 |
| A | SER699 |
| A | PRO700 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | binding site for residue XL6 A 802 |
| Chain | Residue |
| A | CYS488 |
| A | ALA512 |
| A | LYS514 |
| A | GLU531 |
| A | MET535 |
| A | VAL561 |
| A | GLU562 |
| A | TYR563 |
| A | ALA564 |
| A | GLY567 |
| A | ASN568 |
| A | LEU630 |
| A | ALA640 |
| A | ASP641 |
| A | PHE642 |
| A | LEU484 |
| A | GLY487 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 B 801 |
| Chain | Residue |
| B | ARG570 |
| B | HOH909 |
| B | HOH911 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue XL6 B 802 |
| Chain | Residue |
| B | ALA512 |
| B | LYS514 |
| B | GLU531 |
| B | MET535 |
| B | ILE545 |
| B | VAL561 |
| B | GLU562 |
| B | TYR563 |
| B | ALA564 |
| B | GLY567 |
| B | ASN568 |
| B | LEU630 |
| B | ALA640 |
| B | ASP641 |
| B | PHE642 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue XL6 C 801 |
| Chain | Residue |
| C | LEU484 |
| C | VAL492 |
| C | ALA512 |
| C | LYS514 |
| C | GLU531 |
| C | MET535 |
| C | VAL561 |
| C | GLU562 |
| C | TYR563 |
| C | ALA564 |
| C | LEU630 |
| C | ALA640 |
| C | ASP641 |
| C | PHE642 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 D 801 |
| Chain | Residue |
| D | ARG570 |
| D | ARG661 |
| D | LEU662 |
| D | LYS665 |
| D | TRP666 |
| D | SER699 |
| D | PRO700 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 802 |
| Chain | Residue |
| D | THR657 |
| D | ASN659 |
| D | ARG661 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 D 803 |
| Chain | Residue |
| D | PRO579 |
| D | GLY580 |
| D | TYR585 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | binding site for residue XL6 D 804 |
| Chain | Residue |
| D | LYS514 |
| D | GLU531 |
| D | MET535 |
| D | ILE545 |
| D | VAL561 |
| D | GLU562 |
| D | TYR563 |
| D | ALA564 |
| D | SER565 |
| D | LEU630 |
| D | ALA640 |
| D | ASP641 |
| D | PHE642 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 31 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVlAeaigldkdkpnrvtk...VAVK |
| Chain | Residue | Details |
| A | LEU484-LYS514 |
| site_id | PS00109 |
| Number of Residues | 13 |
| Details | PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV |
| Chain | Residue | Details |
| A | CYS619-VAL631 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"16507368","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19665973","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"19224897","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8622701","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
