6NVL

FGFR1 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005007	molecular_function	fibroblast growth factor receptor activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005007	molecular_function	fibroblast growth factor receptor activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005007	molecular_function	fibroblast growth factor receptor activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005007	molecular_function	fibroblast growth factor receptor activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 801

Chain	Residue
A	ARG570
A	ARG661
A	LEU662
A	LYS665
A	TRP666
A	SER699
A	PRO700

---

site_id	AC2
Number of Residues	17
Details	binding site for residue XL6 A 802

Chain	Residue
A	CYS488
A	ALA512
A	LYS514
A	GLU531
A	MET535
A	VAL561
A	GLU562
A	TYR563
A	ALA564
A	GLY567
A	ASN568
A	LEU630
A	ALA640
A	ASP641
A	PHE642
A	LEU484
A	GLY487

---

site_id	AC3
Number of Residues	3
Details	binding site for residue SO4 B 801

Chain	Residue
B	ARG570
B	HOH909
B	HOH911

---

site_id	AC4
Number of Residues	15
Details	binding site for residue XL6 B 802

Chain	Residue
B	ALA512
B	LYS514
B	GLU531
B	MET535
B	ILE545
B	VAL561
B	GLU562
B	TYR563
B	ALA564
B	GLY567
B	ASN568
B	LEU630
B	ALA640
B	ASP641
B	PHE642

---

site_id	AC5
Number of Residues	14
Details	binding site for residue XL6 C 801

Chain	Residue
C	LEU484
C	VAL492
C	ALA512
C	LYS514
C	GLU531
C	MET535
C	VAL561
C	GLU562
C	TYR563
C	ALA564
C	LEU630
C	ALA640
C	ASP641
C	PHE642

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 D 801

Chain	Residue
D	ARG570
D	ARG661
D	LEU662
D	LYS665
D	TRP666
D	SER699
D	PRO700

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 D 802

Chain	Residue
D	THR657
D	ASN659
D	ARG661

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 D 803

Chain	Residue
D	PRO579
D	GLY580
D	TYR585

---

site_id	AC9
Number of Residues	13
Details	binding site for residue XL6 D 804

Chain	Residue
D	LYS514
D	GLU531
D	MET535
D	ILE545
D	VAL561
D	GLU562
D	TYR563
D	ALA564
D	SER565
D	LEU630
D	ALA640
D	ASP641
D	PHE642

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	31
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGCFGQVVlAeaigldkdkpnrvtk...VAVK

Chain	Residue	Details
A	LEU484-LYS514

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNVLV

Chain	Residue	Details
A	CYS619-VAL631

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028, ECO:0000269|PubMed:19224897

Chain	Residue	Details
A	ASP623
B	ASP623
C	ASP623
D	ASP623

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING:

Chain	Residue	Details
A	LEU484
B	ASN568
B	ARG627
B	ASP641
C	LEU484
C	LYS514
C	GLU562
C	ASN568
C	ARG627
C	ASP641
D	LEU484
A	LYS514
D	LYS514
D	GLU562
D	ASN568
D	ARG627
D	ASP641
A	GLU562
A	ASN568
A	ARG627
A	ASP641
B	LEU484
B	LYS514
B	GLU562

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701

Chain	Residue	Details
A	TYR463
D	TYR463
D	TYR583
D	TYR585
A	TYR583
A	TYR585
B	TYR463
B	TYR583
B	TYR585
C	TYR463
C	TYR583
C	TYR585

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:16507368, ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:19665973, ECO:0000269|PubMed:8622701

Chain	Residue	Details
A	TYR653
A	TYR654
B	TYR653
B	TYR654
C	TYR653
C	TYR654
D	TYR653
D	TYR654

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:19224897, ECO:0000269|PubMed:8622701

Chain	Residue	Details
A	TYR730
B	TYR730
C	TYR730
D	TYR730

---