6NVL
FGFR1 complex with N-(2-((5-((2,6-dichloro-3,5-dimethoxybenzyl)oxy)pyrimidin-2-yl)amino)-3-methylphenyl)acrylamide
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Fibroblast growth factor receptor 1 | polymer | 309 | 35167.4 | 4 | UniProt (P11362) Pfam (PF07714) In PDB | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
2 | A, B, D | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
3 | A, B, C, D | N-[2-({5-[(2,6-dichloro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl}amino)-3-methylphenyl]propanamide | non-polymer | 491.4 | 4 | Chemie (XL6) | |||
4 | water | water | 18.0 | 42 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 458 - 765 (UniProt: P11362)
PDB | External Database | Details |
---|---|---|
Gly 457 | - | expression tag |
Ser 584 | Cys 584 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 140669.6 | |
Non-Polymers* | Number of molecules | 9 |
Total formula weight | 2445.8 | |
All* | Total formula weight | 143115.4 |