6NV1

Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor

Summary for 6NV1

• Entry DOI: 10.2210/pdb6nv1/pdb
• Related: 6BMZ
• Descriptor: Matrix protein 2, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine, ... (5 entities in total)
• Functional Keywords: proton channel, membrane protein
• Biological source: Influenza A virus (A/Indonesia/CDC1031RE2/2007(H5N1))
• Total number of polymer chains: 8
• Total formula weight: 25172.25

Authors

Thomaston, J.L.,Liu, L.,DeGrado, W.F. (deposition date: 2019-02-04, release date: 2020-01-15, Last modification date: 2023-10-11)

• Primary citation: Thomaston, J.L.,Konstantinidi, A.,Liu, L.,Lambrinidis, G.,Tan, J.,Caffrey, M.,Wang, J.,Degrado, W.F.,Kolocouris, A.; X-ray Crystal Structures of the Influenza M2 Proton Channel Drug-Resistant V27A Mutant Bound to a Spiro-Adamantyl Amine Inhibitor Reveal the Mechanism of Adamantane Resistance.; Biochemistry, 59:627-634, 2020; PubMed: 31894969; DOI: 10.1021/acs.biochem.9b00971

Experimental method

X-RAY DIFFRACTION (2.5 Å)