6NV1
Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015078 | molecular_function | proton transmembrane transporter activity |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0055036 | cellular_component | virion membrane |
| A | 1902600 | biological_process | proton transmembrane transport |
| B | 0015078 | molecular_function | proton transmembrane transporter activity |
| B | 0033644 | cellular_component | host cell membrane |
| B | 0055036 | cellular_component | virion membrane |
| B | 1902600 | biological_process | proton transmembrane transport |
| C | 0015078 | molecular_function | proton transmembrane transporter activity |
| C | 0033644 | cellular_component | host cell membrane |
| C | 0055036 | cellular_component | virion membrane |
| C | 1902600 | biological_process | proton transmembrane transport |
| D | 0015078 | molecular_function | proton transmembrane transporter activity |
| D | 0033644 | cellular_component | host cell membrane |
| D | 0055036 | cellular_component | virion membrane |
| D | 1902600 | biological_process | proton transmembrane transport |
| E | 0015078 | molecular_function | proton transmembrane transporter activity |
| E | 0033644 | cellular_component | host cell membrane |
| E | 0055036 | cellular_component | virion membrane |
| E | 1902600 | biological_process | proton transmembrane transport |
| F | 0015078 | molecular_function | proton transmembrane transporter activity |
| F | 0033644 | cellular_component | host cell membrane |
| F | 0055036 | cellular_component | virion membrane |
| F | 1902600 | biological_process | proton transmembrane transport |
| G | 0015078 | molecular_function | proton transmembrane transporter activity |
| G | 0033644 | cellular_component | host cell membrane |
| G | 0055036 | cellular_component | virion membrane |
| G | 1902600 | biological_process | proton transmembrane transport |
| H | 0015078 | molecular_function | proton transmembrane transporter activity |
| H | 0033644 | cellular_component | host cell membrane |
| H | 0055036 | cellular_component | virion membrane |
| H | 1902600 | biological_process | proton transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 101 |
| Chain | Residue |
| B | ARG45 |
| C | VAL28 |
| C | ILE32 |
| C | ILE33 |
| site_id | AC2 |
| Number of Residues | 8 |
| Details | binding site for residue E01 A 102 |
| Chain | Residue |
| B | SER31 |
| D | ALA30 |
| D | SER31 |
| A | ALA27 |
| A | ALA30 |
| A | SER31 |
| A | HOH201 |
| A | HOH202 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue OLC B 101 |
| Chain | Residue |
| B | LEU40 |
| B | LEU43 |
| B | ASP44 |
| C | LEU46 |
| G | LEU46 |
| H | VAL28 |
| H | ILE32 |
| H | ILE33 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue OLC D 101 |
| Chain | Residue |
| A | PRO25 |
| A | ALA29 |
| C | LEU40 |
| C | ASP44 |
| D | TRP41 |
| D | ARG45 |
| H | LEU43 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue OLC E 101 |
| Chain | Residue |
| E | LEU36 |
| G | PRO25 |
| G | VAL28 |
| G | ALA29 |
| G | ILE32 |
| G | ILE33 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue OLC E 102 |
| Chain | Residue |
| E | TRP41 |
| E | LEU46 |
| H | ASP44 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue OLC F 101 |
| Chain | Residue |
| A | LEU46 |
| F | ALA29 |
| F | ILE32 |
| F | ILE33 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue E01 F 102 |
| Chain | Residue |
| F | ALA27 |
| F | ALA30 |
| F | SER31 |
| F | HOH202 |
| F | HOH203 |
| G | ALA27 |
| G | SER31 |
| H | SER31 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue OLC G 101 |
| Chain | Residue |
| G | ARG45 |
| G | LEU46 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue OLC H 101 |
| Chain | Residue |
| E | ILE32 |
| G | ASP44 |
| H | LEU46 |
| site_id | AD2 |
| Number of Residues | 1 |
| Details | binding site for residue CL H 102 |
| Chain | Residue |
| H | TRP41 |
| site_id | AD3 |
| Number of Residues | 4 |
| Details | binding site for Di-peptide LEU B 46 and NH2 B 47 |
| Chain | Residue |
| B | ILE42 |
| B | LEU43 |
| B | ASP44 |
| B | ARG45 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide LEU C 46 and NH2 C 47 |
| Chain | Residue |
| B | OLC101 |
| C | ILE42 |
| C | LEU43 |
| C | ASP44 |
| C | ARG45 |
| D | PRO25 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide LEU D 46 and NH2 D 47 |
| Chain | Residue |
| D | ILE42 |
| D | LEU43 |
| D | ASP44 |
| D | ARG45 |
| E | PRO25 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide LEU E 46 and NH2 E 47 |
| Chain | Residue |
| E | ILE42 |
| E | LEU43 |
| E | ASP44 |
| E | ARG45 |
| E | OLC102 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for Di-peptide LEU F 46 and NH2 F 47 |
| Chain | Residue |
| F | ILE42 |
| F | LEU43 |
| F | ASP44 |
| F | ARG45 |
| site_id | AD8 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide LEU G 46 and NH2 G 47 |
| Chain | Residue |
| B | OLC101 |
| G | ILE42 |
| G | LEU43 |
| G | ASP44 |
| G | ARG45 |
| G | OLC101 |
| H | PRO25 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for Di-peptide LEU H 46 and NH2 H 47 |
| Chain | Residue |
| A | PRO25 |
| H | ILE42 |
| H | LEU43 |
| H | ASP44 |
| H | ARG45 |
| H | OLC101 |
