6NV1
Structure of drug-resistant V27A mutant of the influenza M2 proton channel bound to spiroadamantyl amine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Matrix protein 2 | polymer | 27 | 2726.3 | 8 | UniProt (A4D7H3) | Influenza A virus | Proton channel protein M2 |
| 2 | I, K, M, N, O... (A, B, D, E, F...) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 8 | Chemie (OLC) | |||
| 3 | J, Q (A, F) | (1r,1'S,3'S,5'S,7'S)-spiro[cyclohexane-1,2'-tricyclo[3.3.1.1~3,7~]decan]-4-amine | non-polymer | 219.4 | 2 | Chemie (E01) | |||
| 4 | L, T (B, H) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 5 | AA, BA, U, V, W... (G, H, A, B, C...) | water | water | 18.0 | 30 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H: 22 - 46 (UniProt: A4D7H3)
| PDB | External Database | Details |
|---|---|---|
| Ace 21 | - | acetylation |
| Nh2 47 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 8 |
| Total formula weight | 21810.3 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 3362.0 | |
| All* | Total formula weight | 25172.3 |
