6NT4
Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2.
Summary for 6NT4
Entry DOI | 10.2210/pdb6nt4/pdb |
Related | 6NT3 |
EMDB information | 0500 0501 |
Descriptor | Sodium channel protein PaFPC1,Sodium channel protein type 9 subunit alpha,Sodium channel protein PaFPC1, Alpha-mammal toxin AaH2, beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
Functional Keywords | sodium channel, scorpion toxin, electrical signaling, fast inactivation, membrane protein |
Biological source | Periplaneta americana (American cockroach) More |
Total number of polymer chains | 3 |
Total formula weight | 201449.97 |
Authors | Clairfeuille, T.,Rohou, A.,Payandeh, J. (deposition date: 2019-01-28, release date: 2019-02-20, Last modification date: 2021-08-25) |
Primary citation | Clairfeuille, T.,Cloake, A.,Infield, D.T.,Llongueras, J.P.,Arthur, C.P.,Li, Z.R.,Jian, Y.,Martin-Eauclaire, M.F.,Bougis, P.E.,Ciferri, C.,Ahern, C.A.,Bosmans, F.,Hackos, D.H.,Rohou, A.,Payandeh, J. Structural basis of alpha-scorpion toxin action on Na v channels. Science, 363:-, 2019 Cited by PubMed: 30733386DOI: 10.1126/science.aav8573 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
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