Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6NT4

Cryo-EM structure of a human-cockroach hybrid Nav channel bound to alpha-scorpion toxin AaH2.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001518	cellular_component	voltage-gated sodium channel complex
A	0005216	molecular_function	monoatomic ion channel activity
A	0005248	molecular_function	voltage-gated sodium channel activity
A	0005261	molecular_function	monoatomic cation channel activity
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006814	biological_process	sodium ion transport
A	0016020	cellular_component	membrane
A	0055085	biological_process	transmembrane transport
B	0005576	cellular_component	extracellular region
B	0006952	biological_process	defense response
B	0008200	molecular_function	ion channel inhibitor activity
B	0017080	molecular_function	sodium channel regulator activity
B	0019871	molecular_function	sodium channel inhibitor activity
B	0044487	biological_process	venom-mediated perturbation of transmission of nerve impulse
B	0044493	biological_process	venom-mediated inhibition of voltage-gated sodium channel activity
B	0044742	biological_process	venom-mediated increase of sensory perception of pain
B	0090729	molecular_function	toxin activity
B	0099106	molecular_function	ion channel regulator activity
C	0005576	cellular_component	extracellular region
C	0006952	biological_process	defense response
C	0008200	molecular_function	ion channel inhibitor activity
C	0017080	molecular_function	sodium channel regulator activity
C	0019871	molecular_function	sodium channel inhibitor activity
C	0044487	biological_process	venom-mediated perturbation of transmission of nerve impulse
C	0044493	biological_process	venom-mediated inhibition of voltage-gated sodium channel activity
C	0044742	biological_process	venom-mediated increase of sensory perception of pain
C	0090729	molecular_function	toxin activity
C	0099106	molecular_function	ion channel regulator activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	278
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	179
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	87
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI17
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI18
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI19
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI20
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI21
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI22
Number of Residues	101
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI23
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI24
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI25
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI26
Number of Residues	17
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI27
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI28
Number of Residues	13
Details	Region: {"description":"Linker region that may regulate channel inactivation","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000303"}]}

Chain

Residue

Details

site_id	SWS_FT_FI29
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A91","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI30
Number of Residues	5
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6A95","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI31
Number of Residues	7
Details	Site: {"description":"Interacts with the spider Mu-diguetoxin-Dc1a","evidences":[{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI32
Number of Residues	3
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J8G","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6J8J","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI33
Number of Residues	5
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30049784","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A90","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A91","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6A95","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI34
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI35
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine; atypical","evidences":[{"source":"PubMed","id":"28183995","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5X0M","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI36
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI37
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI38
Number of Residues	138
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI39
Number of Residues	18
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI40
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI41
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI42
Number of Residues	50
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI43
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat I","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI44
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI45
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI46
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI47
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI48
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI49
Number of Residues	26
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat II","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI50
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI51
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI52
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI53
Number of Residues	16
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI54
Number of Residues	24
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI55
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat III","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI56
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S1 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI57
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S2 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI58
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=S3 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI59
Number of Residues	19
Details	Transmembrane: {"description":"Helical; Name=S4 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI60
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=S5 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI61
Number of Residues	25
Details	Transmembrane: {"description":"Helical; Name=S6 of repeat IV","evidences":[{"source":"PubMed","id":"30765606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6J8I","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI62
Number of Residues	2
Details	Site: {"description":"Is directly targeted by the spider protoxin-II","evidences":[{"source":"PubMed","id":"30661758","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI63
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"25240195","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI64
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI65
Number of Residues	124
Details	Domain: {"description":"LCN-type CS-alpha/beta","evidences":[{"source":"PROSITE-ProRule","id":"PRU01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI66
Number of Residues	4
Details	Site: {"description":"Key residue for Nav1.7/SCN9A site 3","evidences":[{"source":"PubMed","id":"30733386","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI67
Number of Residues	2
Details	Modified residue: {"description":"Histidine amide","evidences":[{"source":"PubMed","id":"15725394","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)