6NNA

Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and Compound 22

Summary for 6NNA

• Entry DOI: 10.2210/pdb6nna/pdb
• Descriptor: Fatty acid synthase,Fatty acid synthase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {4-[4-(1,3-benzoxazol-2-yl)benzene-1-carbonyl]piperazin-1-yl}(1-hydroxycyclopropyl)methanone, ... (5 entities in total)
• Functional Keywords: fatty acid synthase, human fas, keto-reductase, transferase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 147010.77

Authors

Toms, A.V.,Martin, M.W. (deposition date: 2019-01-14, release date: 2019-02-20, Last modification date: 2023-10-11)

• Primary citation: Martin, M.W.,Lancia Jr., D.R.,Li, H.,Schiller, S.E.R.,Toms, A.V.,Wang, Z.,Bair, K.W.,Castro, J.,Fessler, S.,Gotur, D.,Hubbs, S.E.,Kauffman, G.S.,Kershaw, M.,Luke, G.P.,McKinnon, C.,Yao, L.,Lu, W.,Millan, D.S.; Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN).; Bioorg. Med. Chem. Lett., 29:1001-1006, 2019; PubMed: 30803804; DOI: 10.1016/j.bmcl.2019.02.012

Experimental method

X-RAY DIFFRACTION (2.26 Å)