6NNA

Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and Compound 22

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Fatty acid synthase,Fatty acid synthase	polymer	660	71965.1	2	UniProt (P49327) Pfam (PF08242) Pfam (PF21149) Pfam (PF08659) In PDB	Homo sapiens (Human)
2	A, B	NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE	non-polymer		745.4	2	Chemie (NDP)
3	A, B	{4-[4-(1,3-benzoxazol-2-yl)benzene-1-carbonyl]piperazin-1-yl}(1-hydroxycyclopropyl)methanone	non-polymer		391.4	2	Chemie (KUA)
4	A, B	1,2-ETHANEDIOL	non-polymer		62.1	13	Chemie (EDO)
5		water	water		18.0	594	Chemie (HOH)

Sequence modifications

A, B: 1109 - 1876 (UniProt: P49327)

PDB	External Database	Details
Ala 1438	Ser 1438	engineered mutation
Gly 1876	Pro 1524	engineered mutation

A, B: 1877 - 2114 (UniProt: P49327)

PDB	External Database	Details
His 2115	-	expression tag
His 2116	-	expression tag
His 2117	-	expression tag
His 2118	-	expression tag
His 2119	-	expression tag
His 2120	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	143930.2
Non-Polymers*	Number of molecules	17
	Total formula weight	3080.6
All*	Total formula weight	147010.8

*Water molecules are not included.