6NNA
Human Fatty Acid Synthase Psi/KR Tri-Domain with NADPH and Compound 22
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | binding site for residue NDP A 2201 |
| Chain | Residue |
| A | GLY1891 |
| A | SER1947 |
| A | LEU1971 |
| A | ALA1972 |
| A | VAL1973 |
| A | LYS1995 |
| A | PHE2019 |
| A | SER2020 |
| A | TYR2034 |
| A | TRP2060 |
| A | GLY2061 |
| A | GLY1894 |
| A | ILE2063 |
| A | GLY2067 |
| A | ILE2068 |
| A | LEU2069 |
| A | KUA2202 |
| A | HOH2354 |
| A | HOH2388 |
| A | HOH2412 |
| A | HOH2423 |
| A | HOH2455 |
| A | GLY1895 |
| A | HOH2492 |
| B | ARG1976 |
| A | PHE1896 |
| A | THR1915 |
| A | SER1916 |
| A | ARG1917 |
| A | SER1918 |
| A | ASN1945 |
| site_id | AC2 |
| Number of Residues | 19 |
| Details | binding site for residue KUA A 2202 |
| Chain | Residue |
| A | HIS1263 |
| A | PRO1264 |
| A | SER2021 |
| A | VAL2022 |
| A | SER2023 |
| A | ARG2026 |
| A | ASN2028 |
| A | GLN2031 |
| A | TYR2034 |
| A | ILE2068 |
| A | LEU2069 |
| A | VAL2080 |
| A | SER2081 |
| A | THR2083 |
| A | PHE2109 |
| A | NDP2201 |
| A | HOH2314 |
| A | HOH2317 |
| A | HOH2375 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 2203 |
| Chain | Residue |
| A | ASN1945 |
| B | THR1984 |
| B | PHE1987 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 2204 |
| Chain | Residue |
| A | THR1120 |
| A | GLU1124 |
| A | PRO1222 |
| A | ALA1223 |
| A | PHE1517 |
| A | HOH2340 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 2205 |
| Chain | Residue |
| A | PRO1236 |
| A | ASP1311 |
| A | ARG1337 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 2206 |
| Chain | Residue |
| A | ASN1234 |
| A | PRO1236 |
| A | ARG1404 |
| A | ARG1461 |
| A | ASN1467 |
| A | ARG1470 |
| A | HOH2303 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 2207 |
| Chain | Residue |
| A | GLU1115 |
| A | LYS1225 |
| A | PRO1262 |
| A | HIS1516 |
| A | ARG2026 |
| A | PHE2109 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 2208 |
| Chain | Residue |
| A | THR1123 |
| A | LEU1388 |
| A | GLY1390 |
| A | LEU1391 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue EDO A 2209 |
| Chain | Residue |
| A | ILE1446 |
| A | ASN1447 |
| A | CYS1448 |
| A | LEU1474 |
| A | SER1475 |
| A | ASN1476 |
| site_id | AD1 |
| Number of Residues | 28 |
| Details | binding site for residue NDP B 2201 |
| Chain | Residue |
| B | SER2020 |
| B | SER2021 |
| B | TYR2034 |
| B | TRP2060 |
| B | GLY2061 |
| B | ILE2063 |
| B | GLY2067 |
| B | ILE2068 |
| B | LEU2069 |
| B | KUA2202 |
| B | HOH2352 |
| B | HOH2361 |
| B | HOH2373 |
| B | HOH2470 |
| B | GLY1891 |
| B | GLY1894 |
| B | GLY1895 |
| B | PHE1896 |
| B | THR1915 |
| B | SER1916 |
| B | ARG1917 |
| B | SER1918 |
| B | ASN1945 |
| B | LEU1971 |
| B | ALA1972 |
| B | VAL1973 |
| B | LYS1995 |
| B | PHE2019 |
| site_id | AD2 |
| Number of Residues | 17 |
| Details | binding site for residue KUA B 2202 |
| Chain | Residue |
| B | HIS1263 |
| B | PRO1264 |
| B | SER2021 |
| B | VAL2022 |
| B | SER2023 |
| B | ARG2026 |
| B | ASN2028 |
| B | GLN2031 |
| B | TYR2034 |
| B | VAL2080 |
| B | SER2081 |
| B | THR2083 |
| B | PHE2109 |
| B | NDP2201 |
| B | HOH2309 |
| B | HOH2378 |
| B | HOH2381 |
| site_id | AD3 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 2203 |
| Chain | Residue |
| B | ILE1446 |
| B | ASN1447 |
| B | CYS1448 |
| B | LEU1474 |
| B | ASN1476 |
| B | HOH2326 |
| site_id | AD4 |
| Number of Residues | 5 |
| Details | binding site for residue EDO B 2204 |
| Chain | Residue |
| B | GLU1124 |
| B | ALA1223 |
| B | ALA1226 |
| B | PHE1517 |
| B | HOH2304 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue EDO B 2205 |
| Chain | Residue |
| B | CYS1992 |
| B | LYS1993 |
| B | TYR1996 |
| B | SER1997 |
| site_id | AD6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO B 2206 |
| Chain | Residue |
| B | ASN1234 |
| B | PRO1236 |
| B | ARG1461 |
| B | ASN1467 |
| B | ARG1470 |
| B | HOH2364 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO B 2207 |
| Chain | Residue |
| B | GLU1115 |
| B | LYS1225 |
| B | PRO1262 |
| B | HIS1263 |
| B | HIS1516 |
| B | ARG2026 |
| B | HOH2354 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 2208 |
| Chain | Residue |
| B | HIS2103 |
| B | MET2104 |
| B | HOH2433 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"26851298","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
