6NIP

Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ1 in complex with ZIKV E glycoprotein

6NIP の概要

• エントリーDOI: 10.2210/pdb6nip/pdb
• 分子名称: MZ1 Heavy chain, MZ1 Light Chain, Envelope protein E (3 entities in total)
• 機能のキーワード: zikv-denv, antibody, human, vaccination, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 190613.40

構造登録者

Sankhala, R.S.,Dussupt, V.,Donofrio, G.,Choe, M.,Modjarrad, K.,Michael, N.L.,Krebs, S.J.,Joyce, M.G. (登録日: 2018-12-31, 公開日: 2019-12-25, 最終更新日: 2023-10-11)

• 主引用文献: Dussupt, V.,Sankhala, R.S.,Gromowski, G.D.,Donofrio, G.,De La Barrera, R.A.,Larocca, R.A.,Zaky, W.,Mendez-Rivera, L.,Choe, M.,Davidson, E.,McCracken, M.K.,Brien, J.D.,Abbink, P.,Bai, H.,Bryan, A.L.,Bias, C.H.,Berry, I.M.,Botero, N.,Cook, T.,Doria-Rose, N.A.,Escuer, A.G.I.,Frimpong, J.A.,Geretz, A.,Hernandez, M.,Hollidge, B.S.,Jian, N.,Kabra, K.,Leggat, D.J.,Liu, J.,Pinto, A.K.,Rutvisuttinunt, W.,Setliff, I.,Tran, U.,Townsley, S.,Doranz, B.J.,Rolland, M.,McDermott, A.B.,Georgiev, I.S.,Thomas, R.,Robb, M.L.,Eckels, K.H.,Barranco, E.,Koren, M.,Smith, D.R.,Jarman, R.G.,George, S.L.,Stephenson, K.E.,Barouch, D.H.,Modjarrad, K.,Michael, N.L.,Joyce, M.G.,Krebs, S.J.; Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor.; Nat Med, 26:228-235, 2020; PubMed: 32015557; DOI: 10.1038/s41591-019-0746-2

実験手法

X-RAY DIFFRACTION (4.16 Å)