6N46

Crystal structure of the cryptic polo box domain of a human activated Plk4

Summary for 6N46

Entry DOI	10.2210/pdb6n46/pdb
Descriptor	Serine/threonine-protein kinase PLK4 (1 entity in total)
Functional Keywords	polo-like kinase 4, protein phosphorylation, centriole duplication, pcm organization, phase separation, cell cycle
Biological source	Homo sapiens (Human)
Total number of polymer chains	8
Total formula weight	230542.03
Authors	Park, J.-E.,DiMaio, F.,Zhang, L.,Lee, K.S. (deposition date: 2018-11-17, release date: 2019-09-04, Last modification date: 2023-10-11)
Primary citation	Park, J.E.,Zhang, L.,Bang, J.K.,Andresson, T.,DiMaio, F.,Lee, K.S. Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis. Nat Commun, 10:4959-4959, 2019 Cited by PubMed: 31672968 DOI: 10.1038/s41467-019-12619-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.708 Å)

Structure validation