6N46

Crystal structure of the cryptic polo box domain of a human activated Plk4

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E...	Serine/threonine-protein kinase PLK4	polymer	249	28817.8	8	UniProt (O00444) Pfam (PF18190) Pfam (PF18409) In PDB	Homo sapiens (Human)	Polo-like kinase 4,PLK-4,Serine/threonine-protein kinase 18,Serine/threonine-protein kinase Sak

Sequence modifications

A, B, C, D, E, F, G, H: -4 - 223 (UniProt: O00444)

PDB	External Database	Details
Met -25	-	initiating methionine
Gly -24	-	expression tag
Ser -23	-	expression tag
Ser -22	-	expression tag
His -21	-	expression tag
His -20	-	expression tag
His -19	-	expression tag
His -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
Ser -15	-	expression tag
Ser -14	-	expression tag
Gly -13	-	expression tag
Leu -12	-	expression tag
Val -11	-	expression tag
Pro -10	-	expression tag
Arg -9	-	expression tag
Gly -8	-	expression tag
Ser -7	-	expression tag
His -6	-	expression tag
Met -5	-	expression tag
Glu 113	Ser 698	conflict
Glu 115	Ser 700	conflict
Glu 119	Thr 704	conflict
Asp 122	Thr 707	conflict

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	230542.0
All*	Total formula weight	230542.0

*Water molecules are not included.