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6MZW

TAS-120 covalent complex with FGFR1

Summary for 6MZW
Entry DOI10.2210/pdb6mzw/pdb
Related6MZQ
DescriptorFibroblast growth factor receptor 1, 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one, SULFATE ION, ... (4 entities in total)
Functional Keywordsfgfr1, tas-120, inhibitor, complex, covalent, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight71704.31
Authors
Kalyukina, M.,Squire, C.J. (deposition date: 2018-11-05, release date: 2019-01-16, Last modification date: 2023-10-11)
Primary citationKalyukina, M.,Yosaatmadja, Y.,Middleditch, M.J.,Patterson, A.V.,Smaill, J.B.,Squire, C.J.
TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure.
ChemMedChem, 14:494-500, 2019
Cited by
PubMed: 30600916
DOI: 10.1002/cmdc.201800719
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.2 Å)
Structure validation

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