6MZW
TAS-120 covalent complex with FGFR1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Fibroblast growth factor receptor 1 | polymer | 311 | 35385.7 | 2 | UniProt (P11362) Pfam (PF07714) In PDB | Homo sapiens (Human) | FGFR-1,Basic fibroblast growth factor receptor 1,bFGF-R-1,Fms-like tyrosine kinase 2,FLT-2,N-sam,Proto-oncogene c-Fgr |
| 2 | A, B | 1-[(3S)-3-{4-amino-3-[(3,5-dimethoxyphenyl)ethynyl]-1H-pyrazolo[3,4-d]pyrimidin-1-yl}pyrrolidin-1-yl]prop-2-en-1-one | non-polymer | 418.4 | 2 | Chemie (TZ0) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | water | water | 18.0 | 48 | Chemie (HOH) |
Sequence modifications
A, B: 459 - 765 (UniProt: P11362)
| PDB | External Database | Details |
|---|---|---|
| Gly 455 | - | expression tag |
| Ala 456 | - | expression tag |
| Met 457 | - | expression tag |
| Ser 458 | - | expression tag |
| Ser 584 | Cys 493 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70771.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 933.0 | |
| All* | Total formula weight | 71704.3 |
