6MN4

Crystal structure of aminoglycoside acetyltransferase AAC(3)-IVa, H154A mutant, in complex with apramycin

Summary for 6MN4

Entry DOI	10.2210/pdb6mn4/pdb
Descriptor	Aminoglycoside N(3)-acetyltransferase, AAC(3)-IVa, APRAMYCIN, ZINC ION, ... (8 entities in total)
Functional Keywords	antibiotic_nat family, acetyltransferase, aminoglycoside, antibiotic resistance, coenzyme a, apramycin, aac(3)-iva, csgid, transferase, center for structural genomics of infectious diseases, national institute of allergy and infectious diseases, niaid, transferase-antibiotic complex, transferase/antibiotic
Biological source	Escherichia coli
Total number of polymer chains	6
Total formula weight	174397.77
Authors	Stogios, P.J.,Evdokimova, E.,Michalska, K.,Di Leo, R.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2018-10-01, release date: 2018-10-24, Last modification date: 2023-10-11)
Primary citation	Stogios, P.J.,Bordeleau, E.,Xu, Z.,Skarina, T.,Evdokimova, E.,Chou, S.,Diorio-Toth, L.,D'Souza, A.W.,Patel, S.,Dantas, G.,Wright, G.D.,Savchenko, A. Structural and molecular rationale for the diversification of resistance mediated by the Antibiotic_NAT family. Commun Biol, 5:263-263, 2022 Cited by PubMed: 35338238 DOI: 10.1038/s42003-022-03219-w PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation