6MF2
Improved Model of Human Coagulation Factor VIII
Summary for 6MF2
Entry DOI | 10.2210/pdb6mf2/pdb |
Related | 2R7E 6MF0 |
Descriptor | Coagulation factor VIII, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... (6 entities in total) |
Functional Keywords | factor viii, hemophilia a, hemostasis, secreted, blood clotting |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 175837.85 |
Authors | Smith, I.W.,Spiegel, P.C. (deposition date: 2018-09-08, release date: 2019-09-11, Last modification date: 2020-07-29) |
Primary citation | Smith, I.W.,d'Aquino, A.E.,Coyle, C.W.,Fedanov, A.,Parker, E.T.,Denning, G.,Spencer, H.T.,Lollar, P.,Doering, C.B.,Spiegel Jr., P.C. The 3.2 angstrom structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain. J.Thromb.Haemost., 18:57-69, 2020 Cited by PubMed: 31454152DOI: 10.1111/jth.14621 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.6093641312 Å) |
Structure validation
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