6MCQ
L. pneumophila effector kinase LegK7 in complex with human MOB1A
Summary for 6MCQ
Entry DOI | 10.2210/pdb6mcq/pdb |
Related | 6MCP |
Descriptor | LegK7, MOB kinase activator 1A, DI(HYDROXYETHYL)ETHER, ... (7 entities in total) |
Functional Keywords | translocated effector, ser/thr protein kinase, allosteric activation, hippo pathway, transferase |
Biological source | Legionella pneumophila subsp. pneumophila More |
Total number of polymer chains | 4 |
Total formula weight | 168354.70 |
Authors | Beyrakhova, K.A.,Xu, C.,Boniecki, M.T.,Cygler, M. (deposition date: 2018-09-01, release date: 2019-09-04, Last modification date: 2024-03-13) |
Primary citation | Lee, P.C.,Beyrakhova, K.,Xu, C.,Boniecki, M.T.,Lee, M.H.,Onu, C.J.,Grishin, A.M.,Machner, M.P.,Cygler, M. TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation. Proc.Natl.Acad.Sci.USA, 117:14433-14443, 2020 Cited by PubMed: 32513747DOI: 10.1073/pnas.2000497117 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.57 Å) |
Structure validation
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