6M8S
Crystal structure of the KCTD12 H1 domain in complex with Gbeta1gamma2 subunits
Summary for 6M8S
Entry DOI | 10.2210/pdb6m8s/pdb |
Related | 6M8R |
Descriptor | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, BTB/POZ domain-containing protein KCTD12 (3 entities in total) |
Functional Keywords | beta-propeller, homopentamer, gabab desensitization, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 15 |
Total formula weight | 304886.23 |
Authors | Zheng, S.,Kruse, A.C. (deposition date: 2018-08-22, release date: 2019-02-27, Last modification date: 2023-10-11) |
Primary citation | Zheng, S.,Abreu, N.,Levitz, J.,Kruse, A.C. Structural basis for KCTD-mediated rapid desensitization of GABABsignalling. Nature, 567:127-131, 2019 Cited by PubMed: 30814734DOI: 10.1038/s41586-019-0990-0 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.71 Å) |
Structure validation
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