6M8P

Human ERAP1 bound to phosphinic pseudotripeptide inhibitor DG013

This is a non-PDB format compatible entry.

Summary for 6M8P

• Entry DOI: 10.2210/pdb6m8p/pdb
• Descriptor: Endoplasmic reticulum aminopeptidase 1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (6 entities in total)
• Functional Keywords: inhibitor, aminopeptidase, antigen processing, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 22
• Total formula weight: 2338352.31

Authors

Maben, Z.,Stern, L.J. (deposition date: 2018-08-22, release date: 2019-12-18, Last modification date: 2023-10-11)

• Primary citation: Maben, Z.,Arya, R.,Georgiadis, D.,Stratikos, E.,Stern, L.J.; Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.; Nat Commun, 12:5302-5302, 2021; PubMed: 34489420; DOI: 10.1038/s41467-021-25564-w

Experimental method

X-RAY DIFFRACTION (3.31 Å)