6M8P
Human ERAP1 bound to phosphinic pseudotripeptide inhibitor DG013
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008237 | molecular_function | metallopeptidase activity |
| A | 0008270 | molecular_function | zinc ion binding |
| B | 0006508 | biological_process | proteolysis |
| B | 0008237 | molecular_function | metallopeptidase activity |
| B | 0008270 | molecular_function | zinc ion binding |
| C | 0006508 | biological_process | proteolysis |
| C | 0008237 | molecular_function | metallopeptidase activity |
| C | 0008270 | molecular_function | zinc ion binding |
| D | 0006508 | biological_process | proteolysis |
| D | 0008237 | molecular_function | metallopeptidase activity |
| D | 0008270 | molecular_function | zinc ion binding |
| E | 0006508 | biological_process | proteolysis |
| E | 0008237 | molecular_function | metallopeptidase activity |
| E | 0008270 | molecular_function | zinc ion binding |
| F | 0006508 | biological_process | proteolysis |
| F | 0008237 | molecular_function | metallopeptidase activity |
| F | 0008270 | molecular_function | zinc ion binding |
| G | 0006508 | biological_process | proteolysis |
| G | 0008237 | molecular_function | metallopeptidase activity |
| G | 0008270 | molecular_function | zinc ion binding |
| H | 0006508 | biological_process | proteolysis |
| H | 0008237 | molecular_function | metallopeptidase activity |
| H | 0008270 | molecular_function | zinc ion binding |
| I | 0006508 | biological_process | proteolysis |
| I | 0008237 | molecular_function | metallopeptidase activity |
| I | 0008270 | molecular_function | zinc ion binding |
| J | 0006508 | biological_process | proteolysis |
| J | 0008237 | molecular_function | metallopeptidase activity |
| J | 0008270 | molecular_function | zinc ion binding |
| K | 0006508 | biological_process | proteolysis |
| K | 0008237 | molecular_function | metallopeptidase activity |
| K | 0008270 | molecular_function | zinc ion binding |
| L | 0006508 | biological_process | proteolysis |
| L | 0008237 | molecular_function | metallopeptidase activity |
| L | 0008270 | molecular_function | zinc ion binding |
| M | 0006508 | biological_process | proteolysis |
| M | 0008237 | molecular_function | metallopeptidase activity |
| M | 0008270 | molecular_function | zinc ion binding |
| N | 0006508 | biological_process | proteolysis |
| N | 0008237 | molecular_function | metallopeptidase activity |
| N | 0008270 | molecular_function | zinc ion binding |
| O | 0006508 | biological_process | proteolysis |
| O | 0008237 | molecular_function | metallopeptidase activity |
| O | 0008270 | molecular_function | zinc ion binding |
| P | 0006508 | biological_process | proteolysis |
| P | 0008237 | molecular_function | metallopeptidase activity |
| P | 0008270 | molecular_function | zinc ion binding |
| Q | 0006508 | biological_process | proteolysis |
| Q | 0008237 | molecular_function | metallopeptidase activity |
| Q | 0008270 | molecular_function | zinc ion binding |
| R | 0006508 | biological_process | proteolysis |
| R | 0008237 | molecular_function | metallopeptidase activity |
| R | 0008270 | molecular_function | zinc ion binding |
| S | 0006508 | biological_process | proteolysis |
| S | 0008237 | molecular_function | metallopeptidase activity |
| S | 0008270 | molecular_function | zinc ion binding |
| T | 0006508 | biological_process | proteolysis |
| T | 0008237 | molecular_function | metallopeptidase activity |
| T | 0008270 | molecular_function | zinc ion binding |
| U | 0006508 | biological_process | proteolysis |
| U | 0008237 | molecular_function | metallopeptidase activity |
| U | 0008270 | molecular_function | zinc ion binding |
| V | 0006508 | biological_process | proteolysis |
| V | 0008237 | molecular_function | metallopeptidase activity |
| V | 0008270 | molecular_function | zinc ion binding |
Functional Information from PROSITE/UniProt
| site_id | PS00142 |
| Number of Residues | 10 |
| Details | ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. TVAHELAHQW |
| Chain | Residue | Details |
| A | THR350-TRP359 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU10095 |
| Chain | Residue | Details |
| A | GLU354 | |
| J | GLU354 | |
| K | GLU354 | |
| L | GLU354 | |
| M | GLU354 | |
| N | GLU354 | |
| O | GLU354 | |
| P | GLU354 | |
| Q | GLU354 | |
| R | GLU354 | |
| S | GLU354 | |
| B | GLU354 | |
| T | GLU354 | |
| U | GLU354 | |
| V | GLU354 | |
| C | GLU354 | |
| D | GLU354 | |
| E | GLU354 | |
| F | GLU354 | |
| G | GLU354 | |
| H | GLU354 | |
| I | GLU354 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 44 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLU183 | |
| E | GLY317 | |
| F | GLU183 | |
| F | GLY317 | |
| G | GLU183 | |
| G | GLY317 | |
| H | GLU183 | |
| H | GLY317 | |
| I | GLU183 | |
| I | GLY317 | |
| J | GLU183 | |
| A | GLY317 | |
| J | GLY317 | |
| K | GLU183 | |
| K | GLY317 | |
| L | GLU183 | |
| L | GLY317 | |
| M | GLU183 | |
| M | GLY317 | |
| N | GLU183 | |
| N | GLY317 | |
| O | GLU183 | |
| B | GLU183 | |
| O | GLY317 | |
| P | GLU183 | |
| P | GLY317 | |
| Q | GLU183 | |
| Q | GLY317 | |
| R | GLU183 | |
| R | GLY317 | |
| S | GLU183 | |
| S | GLY317 | |
| T | GLU183 | |
| B | GLY317 | |
| T | GLY317 | |
| U | GLU183 | |
| U | GLY317 | |
| V | GLU183 | |
| V | GLY317 | |
| C | GLU183 | |
| C | GLY317 | |
| D | GLU183 | |
| D | GLY317 | |
| E | GLU183 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 66 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | HIS353 | |
| D | HIS353 | |
| D | HIS357 | |
| D | GLU376 | |
| E | HIS353 | |
| E | HIS357 | |
| E | GLU376 | |
| F | HIS353 | |
| F | HIS357 | |
| F | GLU376 | |
| G | HIS353 | |
| A | HIS357 | |
| G | HIS357 | |
| G | GLU376 | |
| H | HIS353 | |
| H | HIS357 | |
| H | GLU376 | |
| I | HIS353 | |
| I | HIS357 | |
| I | GLU376 | |
| J | HIS353 | |
| J | HIS357 | |
| A | GLU376 | |
| J | GLU376 | |
| K | HIS353 | |
| K | HIS357 | |
| K | GLU376 | |
| L | HIS353 | |
| L | HIS357 | |
| L | GLU376 | |
| M | HIS353 | |
| M | HIS357 | |
| M | GLU376 | |
| B | HIS353 | |
| N | HIS353 | |
| N | HIS357 | |
| N | GLU376 | |
| O | HIS353 | |
| O | HIS357 | |
| O | GLU376 | |
| P | HIS353 | |
| P | HIS357 | |
| P | GLU376 | |
| Q | HIS353 | |
| B | HIS357 | |
| Q | HIS357 | |
| Q | GLU376 | |
| R | HIS353 | |
| R | HIS357 | |
| R | GLU376 | |
| S | HIS353 | |
| S | HIS357 | |
| S | GLU376 | |
| T | HIS353 | |
| T | HIS357 | |
| B | GLU376 | |
| T | GLU376 | |
| U | HIS353 | |
| U | HIS357 | |
| U | GLU376 | |
| V | HIS353 | |
| V | HIS357 | |
| V | GLU376 | |
| C | HIS353 | |
| C | HIS357 | |
| C | GLU376 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 22 |
| Details | SITE: Transition state stabilizer => ECO:0000250 |
| Chain | Residue | Details |
| A | TYR438 | |
| J | TYR438 | |
| K | TYR438 | |
| L | TYR438 | |
| M | TYR438 | |
| N | TYR438 | |
| O | TYR438 | |
| P | TYR438 | |
| Q | TYR438 | |
| R | TYR438 | |
| S | TYR438 | |
| B | TYR438 | |
| T | TYR438 | |
| U | TYR438 | |
| V | TYR438 | |
| C | TYR438 | |
| D | TYR438 | |
| E | TYR438 | |
| F | TYR438 | |
| G | TYR438 | |
| H | TYR438 | |
| I | TYR438 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 44 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21478864, ECO:0000269|Ref.16 |
| Chain | Residue | Details |
| A | ASN70 | |
| E | ASN154 | |
| F | ASN70 | |
| F | ASN154 | |
| G | ASN70 | |
| G | ASN154 | |
| H | ASN70 | |
| H | ASN154 | |
| I | ASN70 | |
| I | ASN154 | |
| J | ASN70 | |
| A | ASN154 | |
| J | ASN154 | |
| K | ASN70 | |
| K | ASN154 | |
| L | ASN70 | |
| L | ASN154 | |
| M | ASN70 | |
| M | ASN154 | |
| N | ASN70 | |
| N | ASN154 | |
| O | ASN70 | |
| B | ASN70 | |
| O | ASN154 | |
| P | ASN70 | |
| P | ASN154 | |
| Q | ASN70 | |
| Q | ASN154 | |
| R | ASN70 | |
| R | ASN154 | |
| S | ASN70 | |
| S | ASN154 | |
| T | ASN70 | |
| B | ASN154 | |
| T | ASN154 | |
| U | ASN70 | |
| U | ASN154 | |
| V | ASN70 | |
| V | ASN154 | |
| C | ASN70 | |
| C | ASN154 | |
| D | ASN70 | |
| D | ASN154 | |
| E | ASN70 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|Ref.16 |
| Chain | Residue | Details |
| A | ASN414 | |
| J | ASN414 | |
| K | ASN414 | |
| L | ASN414 | |
| M | ASN414 | |
| N | ASN414 | |
| O | ASN414 | |
| P | ASN414 | |
| Q | ASN414 | |
| R | ASN414 | |
| S | ASN414 | |
| B | ASN414 | |
| T | ASN414 | |
| U | ASN414 | |
| V | ASN414 | |
| C | ASN414 | |
| D | ASN414 | |
| E | ASN414 | |
| F | ASN414 | |
| G | ASN414 | |
| H | ASN414 | |
| I | ASN414 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 22 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:21478864 |
| Chain | Residue | Details |
| A | ASN735 | |
| J | ASN735 | |
| K | ASN735 | |
| L | ASN735 | |
| M | ASN735 | |
| N | ASN735 | |
| O | ASN735 | |
| P | ASN735 | |
| Q | ASN735 | |
| R | ASN735 | |
| S | ASN735 | |
| B | ASN735 | |
| T | ASN735 | |
| U | ASN735 | |
| V | ASN735 | |
| C | ASN735 | |
| D | ASN735 | |
| E | ASN735 | |
| F | ASN735 | |
| G | ASN735 | |
| H | ASN735 | |
| I | ASN735 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 22 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN876 | |
| J | ASN876 | |
| K | ASN876 | |
| L | ASN876 | |
| M | ASN876 | |
| N | ASN876 | |
| O | ASN876 | |
| P | ASN876 | |
| Q | ASN876 | |
| R | ASN876 | |
| S | ASN876 | |
| B | ASN876 | |
| T | ASN876 | |
| U | ASN876 | |
| V | ASN876 | |
| C | ASN876 | |
| D | ASN876 | |
| E | ASN876 | |
| F | ASN876 | |
| G | ASN876 | |
| H | ASN876 | |
| I | ASN876 |
