6M8P
Human ERAP1 bound to phosphinic pseudotripeptide inhibitor DG013
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | Endoplasmic reticulum aminopeptidase 1 | polymer | 899 | 102967.2 | 22 | UniProt (Q9NZ08) Pfam (PF17900) Pfam (PF01433) Pfam (PF11838) | Homo sapiens (Human) | ARTS-1,Adipocyte-derived leucine aminopeptidase,A-LAP,Aminopeptidase PILS,Puromycin-insensitive leucyl-specific aminopeptidase,PILS-AP,Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator |
| 2 | AA, AB, BA, BB, CA... (a, 0, b, 1, c...) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 44 | In PDB GlyTouCan (G15407YE) | |||
| 3 | BI, BM, BO, EC, EE... (K, Q, T, B, E...) | ZINC ION | non-polymer | 65.4 | 22 | Chemie (ZN) | |||
| 4 | CI, CM, CO, FC, FE... (K, Q, T, B, E...) | Nalpha-[(2S)-2-{[[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]methyl}-4-methylpentanoyl]-L-tryptophanamide | non-polymer | 512.6 | 22 | Chemie (P52) | |||
| 5 | AC, AD, AE, AF, AG... (A, C, D, F, G...) | SULFATE ION | non-polymer | 96.1 | 309 | Chemie (SO4) | |||
| 6 | AI, AM, BG, CE, CK... (J, P, G, D, M...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 22 | Chemie (NAG) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V: 17 - 915 (UniProt: Q9NZ08)
| PDB | External Database | Details |
|---|---|---|
| His 26 | - | expression tag |
| His 27 | - | expression tag |
| His 28 | - | expression tag |
| His 29 | - | expression tag |
| His 30 | - | expression tag |
| His 31 | - | expression tag |
| His 32 | - | expression tag |
| His 33 | - | expression tag |
| His 34 | - | expression tag |
| His 35 | - | expression tag |
| Glu 38 | - | insertion |
| Asn 39 | - | insertion |
| Leu 40 | - | insertion |
| Tyr 41 | - | insertion |
| Phe 42 | - | insertion |
| Gln 43 | - | insertion |
| - | Cys 486 | deletion |
| - | Pro 487 | deletion |
| - | Thr 488 | deletion |
| - | Asp 489 | deletion |
| - | Gly 490 | deletion |
| - | Val 491 | deletion |
| - | Lys 492 | deletion |
| - | Gly 493 | deletion |
| - | Met 494 | deletion |
| - | Asp 495 | deletion |
| - | Gly 496 | deletion |
| - | Phe 497 | deletion |
| - | Cys 498 | deletion |
| - | Ser 499 | deletion |
| - | Arg 500 | deletion |
| - | Ser 501 | deletion |
| - | Gln 502 | deletion |
| - | His 503 | deletion |
| - | Ser 504 | deletion |
| - | Ser 505 | deletion |
| - | Ser 506 | deletion |
| - | Ser 507 | deletion |
| - | Ser 508 | deletion |
| - | His 509 | deletion |
| - | Trp 510 | deletion |
| Gly 486 | His 511 | linker |
| Gly 487 | Gln 512 | linker |
| Gly 488 | Glu 513 | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 22 |
| Total formula weight | 2265278.6 | |
| Branched | Number of molecules | 44 |
| Total formula weight | 25807.8 | |
| Non-Polymers* | Number of molecules | 375 |
| Total formula weight | 47265.8 | |
| All* | Total formula weight | 2338352.3 |
