6LWB

Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing 5-hydroxyuracil (5-OHU)

Summary for 6LWB

• Entry DOI: 10.2210/pdb6lwb/pdb
• Descriptor: Endonuclease 8-like 1, DNA (5'-D(*CP*GP*TP*CP*CP*AP*(OHU)P*GP*TP*CP*TP*AP*C)-3'), DNA (5'-D(*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*G)-3'), ... (4 entities in total)
• Functional Keywords: base lesion, oxidative dna damage, dna repair, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 9
• Total formula weight: 123627.98

Authors

Liu, M.H.,Zhang, J.,Zhu, C.X.,Zhang, X.X.,Gao, Y.Q.,Yi, C.Q. (deposition date: 2020-02-07, release date: 2021-06-09, Last modification date: 2023-11-29)

• Primary citation: Liu, M.,Zhang, J.,Zhu, C.,Zhang, X.,Xiao, W.,Yan, Y.,Liu, L.,Zeng, H.,Gao, Y.Q.,Yi, C.; DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes.; Nat Commun, 12:4108-4108, 2021; PubMed: 34226550; DOI: 10.1038/s41467-021-24431-y

Experimental method

X-RAY DIFFRACTION (2.55 Å)