6LWB

Crystal structure of human NEIL1(P2G, E3Q, R242) bound to duplex DNA containing 5-hydroxyuracil (5-OHU)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D, G	Endonuclease 8-like 1	polymer	295	33288.2	3	UniProt (Q96FI4) Pfam (PF01149) Pfam (PF09292) In PDB	Homo sapiens (Human)	DNA glycosylase/AP lyase Neil1,DNA-(apurinic or apyrimidinic site) lyase Neil1,Endonuclease VIII-like 1,FPG1,Nei homolog 1,NEH1,Nei-like protein 1
2	B, E, H	DNA (5'-D(*CP*GP*TP*CP*CP*AP*(OHU)P*GP*TP*CP*TP*AP*C)-3')	polymer	13	3904.5	3		Escherichia coli
3	C, F, I	DNA (5'-D(*TP*AP*GP*AP*CP*CP*TP*GP*GP*AP*CP*GP*G)-3')	polymer	13	4016.6	3		Escherichia coli
4		water	water		18.0	260	Chemie (HOH)

Sequence modifications

A, D, G: 1 - 295 (UniProt: Q96FI4)

PDB	External Database	Details
Gly 2	Pro 2	engineered mutation
Gln 3	Glu 3	engineered mutation
Arg 242	Lys 242	variant

Contents of the asymmetric unit

Polymers	Number of chains	9
	Total formula weight	123628.0
All*	Total formula weight	123628.0

*Water molecules are not included.