6KWX

cryo-EM structure of human PA200

Summary for 6KWX

Entry DOI	10.2210/pdb6kwx/pdb
EMDB information	0780
Descriptor	Proteasome activator complex subunit 4, [(1~{S},2~{R},3~{R},4~{S},5~{S},6~{R})-2-[oxidanyl(phosphonooxy)phosphoryl]oxy-3,4,5,6-tetraphosphonooxy-cyclohexyl] phosphono hydrogen phosphate, INOSITOL HEXAKISPHOSPHATE (3 entities in total)
Functional Keywords	proteasome activator, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	217254.90
Authors	Ouyang, S.,Hongxin, G. (deposition date: 2019-09-09, release date: 2020-04-01, Last modification date: 2024-03-27)
Primary citation	Guan, H.,Wang, Y.,Yu, T.,Huang, Y.,Li, M.,Saeed, A.F.U.H.,Perculija, V.,Li, D.,Xiao, J.,Wang, D.,Zhu, P.,Ouyang, S. Cryo-EM structures of the human PA200 and PA200-20S complex reveal regulation of proteasome gate opening and two PA200 apertures. Plos Biol., 18:e3000654-e3000654, 2020 Cited by PubMed: 32134919 DOI: 10.1371/journal.pbio.3000654 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.75 Å)

Structure validation