6KWX
cryo-EM structure of human PA200
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000502 | cellular_component | proteasome complex |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006281 | biological_process | DNA repair |
| A | 0006974 | biological_process | DNA damage response |
| A | 0007283 | biological_process | spermatogenesis |
| A | 0010499 | biological_process | proteasomal ubiquitin-independent protein catabolic process |
| A | 0016504 | molecular_function | peptidase activator activity |
| A | 0016607 | cellular_component | nuclear speck |
| A | 0030154 | biological_process | cell differentiation |
| A | 0030317 | biological_process | flagellated sperm motility |
| A | 0035092 | biological_process | sperm DNA condensation |
| A | 0070628 | molecular_function | proteasome binding |
| A | 1990111 | cellular_component | spermatoproteasome complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | binding site for residue K0W A 1901 |
| Chain | Residue |
| A | LYS30 |
| A | ARG943 |
| A | TYR34 |
| A | ARG84 |
| A | LYS128 |
| A | LYS129 |
| A | TRP915 |
| A | LYS922 |
| A | ARG928 |
| A | LYS933 |
| site_id | AC2 |
| Number of Residues | 14 |
| Details | binding site for residue IHP A 1902 |
| Chain | Residue |
| A | LYS156 |
| A | LYS1213 |
| A | LYS1216 |
| A | HIS1219 |
| A | LYS1221 |
| A | LYS1271 |
| A | TYR1286 |
| A | LYS1346 |
| A | ARG1350 |
| A | ARG1388 |
| A | LYS1391 |
| A | HIS1392 |
| A | SER1434 |
| A | ARG1435 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | Repeat: {"description":"HEAT 1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 39 |
| Details | Repeat: {"description":"HEAT 2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 3"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 4"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 5"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 38 |
| Details | Repeat: {"description":"HEAT 6"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 88 |
| Details | Region: {"description":"Bromodomain-like (BRDL)"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
