6KRO
Tankyrase-2 in complex with RK-582
Summary for 6KRO
Entry DOI | 10.2210/pdb6kro/pdb |
Descriptor | Tankyrase-2, 6-[(2S,6R)-2,6-dimethylmorpholin-4-yl]-4-fluoranyl-1-methyl-1'-(8-methyl-4-oxidanylidene-3,5,6,7-tetrahydropyrido[2,3-d]pyrimidin-2-yl)spiro[indole-3,4'-piperidine]-2-one, ZINC ION, ... (7 entities in total) |
Functional Keywords | tankyrase, parp, adp-ribosylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 25369.83 |
Authors | Niwa, H.,Shirai, F.,Sato, S.,Tsumura, T.,Okue, M.,Shirouzu, M.,Seimiya, H.,Umehara, T. (deposition date: 2019-08-22, release date: 2020-04-01, Last modification date: 2024-03-27) |
Primary citation | Shirai, F.,Mizutani, A.,Yashiroda, Y.,Tsumura, T.,Kano, Y.,Muramatsu, Y.,Chikada, T.,Yuki, H.,Niwa, H.,Sato, S.,Washizuka, K.,Koda, Y.,Mazaki, Y.,Jang, M.K.,Yoshida, H.,Nagamori, A.,Okue, M.,Watanabe, T.,Kitamura, K.,Shitara, E.,Honma, T.,Umehara, T.,Shirouzu, M.,Fukami, T.,Seimiya, H.,Yoshida, M.,Koyama, H. Design and Discovery of an Orally Efficacious Spiroindolinone-Based Tankyrase Inhibitor for the Treatment of Colon Cancer. J.Med.Chem., 63:4183-4204, 2020 Cited by PubMed: 32202790DOI: 10.1021/acs.jmedchem.0c00045 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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