6JEZ

Covalent labeling of rVDR-LBD by turn-on fluorescent probe mediated by conjugate addition and cyclization

Summary for 6JEZ

Entry DOI	10.2210/pdb6jez/pdb
Descriptor	Vitamin D3 receptor,Vitamin D3 receptor, Mediator of RNA polymerase II transcription subunit 1, (1R,3R)-5-(2-((1R,3aS,7aR,E)-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyloctahydro-4H-inden-4-ylidene)ethylidene)-2- methylenecyclohexane-1,3-diol, ... (5 entities in total)
Functional Keywords	hormone, turn-on fluorescent probe, tcc probe, covalent labeling, histidine
Biological source	Rattus norvegicus (Rat) More
Total number of polymer chains	2
Total formula weight	32799.83
Authors	Kojima, H.,Yamamoto, K.,Itoh, T. (deposition date: 2019-02-07, release date: 2020-02-12, Last modification date: 2023-11-22)
Primary citation	Kojima, H.,Fujita, Y.,Takeuchi, R.,Ikebe, Y.,Ohashi, N.,Yamamoto, K.,Itoh, T. Cyclization Reaction-Based Turn-on Probe for Covalent Labeling of Target Proteins. Cell Chem Biol, 27:334-, 2020 Cited by PubMed: 31991094 DOI: 10.1016/j.chembiol.2020.01.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation