6JEZ

Covalent labeling of rVDR-LBD by turn-on fluorescent probe mediated by conjugate addition and cyclization

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue YSV A 501

Chain	Residue
A	TYR143
A	HIS393
A	SER233
A	ARG270
A	SER271
A	SER274
A	TRP282
A	CYS284
A	VAL296
A	HIS301

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EJO A 502

Chain	Residue
A	LEU136
A	ASP137
A	HIS140
A	LYS141

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"Interaction with coactivator LXXLL motif","evidences":[{"source":"PubMed","id":"15065852","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Motif: {"description":"9aaTAD","evidences":[{"source":"UniProtKB","id":"P11473","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15065852","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1RK3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Motif: {"description":"LXXLL motif 2"}

Chain

Residue

Details

---