6IHC

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) Y100A mutant in complex with holo-ACP from Helicobacter pylori

Summary for 6IHC

Entry DOI	10.2210/pdb6ihc/pdb
Descriptor	3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ, holo-form acyl carrier protein (holo-ACP), CITRIC ACID, ... (5 entities in total)
Functional Keywords	dehydrotase, fatty acid biosynthesis, biosynthetic protein
Biological source	Helicobacter pylori (Campylobacter pylori) More
Total number of polymer chains	7
Total formula weight	112243.05
Authors	Shen, S.Q.,Zhang, L.,Zhang, L. (deposition date: 2018-09-29, release date: 2019-04-10)
Primary citation	Shen, S.Q.,Hang, X.D.,Zhuang, J.J.,Zhang, L.,Bi, H.K.,Zhang, L. A back-door Phenylalanine coordinates the stepwise hexameric loading of acyl carrier protein by the fatty acid biosynthesis enzyme beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ). Int. J. Biol. Macromol., 128:5-11, 2019 Cited by PubMed: 30677439 DOI: 10.1016/j.ijbiomac.2019.01.094 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation