6IHC

Crystal structure of (3R)-Hydroxyacyl-Acyl Carrier Protein Dehydratase(FabZ) Y100A mutant in complex with holo-ACP from Helicobacter pylori

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0006633	biological_process	fatty acid biosynthetic process
A	0009245	biological_process	lipid A biosynthetic process
A	0016829	molecular_function	lyase activity
A	0016836	molecular_function	hydro-lyase activity
A	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
B	0005737	cellular_component	cytoplasm
B	0006633	biological_process	fatty acid biosynthetic process
B	0009245	biological_process	lipid A biosynthetic process
B	0016829	molecular_function	lyase activity
B	0016836	molecular_function	hydro-lyase activity
B	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
C	0005737	cellular_component	cytoplasm
C	0006633	biological_process	fatty acid biosynthetic process
C	0009245	biological_process	lipid A biosynthetic process
C	0016829	molecular_function	lyase activity
C	0016836	molecular_function	hydro-lyase activity
C	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
D	0005737	cellular_component	cytoplasm
D	0006633	biological_process	fatty acid biosynthetic process
D	0009245	biological_process	lipid A biosynthetic process
D	0016829	molecular_function	lyase activity
D	0016836	molecular_function	hydro-lyase activity
D	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
E	0005737	cellular_component	cytoplasm
E	0006633	biological_process	fatty acid biosynthetic process
E	0009245	biological_process	lipid A biosynthetic process
E	0016829	molecular_function	lyase activity
E	0016836	molecular_function	hydro-lyase activity
E	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
F	0005737	cellular_component	cytoplasm
F	0006633	biological_process	fatty acid biosynthetic process
F	0009245	biological_process	lipid A biosynthetic process
F	0016829	molecular_function	lyase activity
F	0016836	molecular_function	hydro-lyase activity
F	0019171	molecular_function	(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
G	0006633	biological_process	fatty acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue CIT A 1001

Chain	Residue
A	PRO26
F	ASN51
A	MET27
A	VAL54
A	HOH1102
A	HOH1107
A	HOH1134
B	PRO26
B	MET27
C	ASN51

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site_id	AC2
Number of Residues	11
Details	binding site for residue CIT C 1101

Chain	Residue
B	ASN51
C	PRO26
C	MET27
C	VAL54
C	LEU69
C	HOH1201
C	HOH1210
D	PRO26
D	MET27
D	LEU69
E	ASN51

---

site_id	AC3
Number of Residues	10
Details	binding site for residue CIT F 1001

Chain	Residue
A	ASN51
D	ASN51
E	PRO26
E	MET27
E	LEU69
F	PRO26
F	MET27
F	LEU69
F	HOH1103
F	HOH1114

---

site_id	AC4
Number of Residues	13
Details	binding site for Di-peptide PN7 G 101 and SER G 36

Chain	Residue
A	ILE64
A	PHE65
A	GLY67
A	PHE109
A	ARG110
B	PHE101
G	ASP35
G	LEU37
G	ASP38
G	VAL39
G	VAL40
G	HOH204
G	HOH205

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Functional Information from PROSITE/UniProt

site_id	PS00012
Number of Residues	16
Details	PHOSPHOPANTETHEINE Phosphopantetheine attachment site. DLGADSLDVVELIMAL

Chain	Residue	Details
G	ASP31-LEU46

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: O-(pantetheine 4'-phosphoryl)serine => ECO:0000255|PROSITE-ProRule:PRU00258

Chain	Residue	Details
G	SER36

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